Joe Turner's Come and Gone is a play by American playwright, August Wilson, the second installment of his decade-by-decade chronicle of the African-American experience, The Pittsburgh Cycle. The play was first staged 1984 at the Eugene O'Neill Theater Center in Waterford, Connecticut and opened on Broadway on 27 March 1988 at the Ethel Barrymore Theatre and ran for 105 performances. Directed by Lloyd Richards, the cast included Delroy Lindo as Herald Loomis and television and movie star Angela Bassett as Loomis's wife, Martha.

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The original working title of the play was Mill Hand's Lunch Bucket, the title of a painting by Romare Bearden. The title Joe Turner's Come and Gone is a line from the refrain of "Joe Turner", an early blues song.Big Bill Broonzy, Alan Lomax: Blues Songbook, disc 2.