The Caroline Rhea Show is an American syndicated variety/talk show that was regarded as the successor to The Rosie O'Donnell Show. It premiered in September 2002 until 2003 and was hosted by actress and comedienne Caroline Rhea, who was hand-picked by Rosie O'Donnell as her replacement and who had hosted the last few weeks of Rosie prior to her show launching. Like its predecessor, The Caroline Rhea Show was taped in Studio 8-G at NBC's Rockefeller Center Studios in New York City.

In many ways, The Caroline Rhea Show was similar to the more-successful Ellen DeGeneres Show; both programs were daytime talk shows that were run like nighttime talk shows, with monologues and house bands and celebrity (and sometimes non-celebrity) guests. Unlike with Rosie's daytime show where an audience member opened the show, by announcing the day's guests, Chip Zion was the announcer of the show announcing "Live from New York it's the Caroline Rhea Show! On Today's Show... Here's Caroline!"

Most television markets which had aired the show replaced it with The Ellen DeGeneres Show, which was offered by the syndicator of both Rhea's and O'Donnell's show, Warner Bros. Television's Telepictures division. Some stations that aired Rosie also aired Caroline Rhea, but some (like WABC in New York, which gave the former Rosie spot to The Wayne Brady Show) moved the show to an undesirable late-night time slot.