Wayne Kramer (born 1965, Johannesburg-Kew South Africa) is a screenwriter and film director.

Kramer has written and directed films such as The Cooler, Crossing Over, Blazeland, and Running Scared, which starred Paul Walker. He also wrote the screenplay for the film Mindhunters, but the final script was heavily rewritten by others and bore little resemblance to Kramer's original work. He was also one of the featured filmmakers interviewed for the Kirby Dick documentary This Film is Not Yet Rated, in which he discusses the apparent absurdity of the fact his film The Cooler was given an NC-17 certificate by the MPAA simply due to a few seconds long shot of its lead actress' pubic hair.

In 2007, Kramer directed the film "Crossing Over." The film is a "Traffic" like ensemble drama about immigration in Los Angeles and stars Harrison Ford, Sean Penn, Ray Liotta, Ashley Judd, Cliff Curtis, Summer Bishil, Jim Sturgess, Alice Eve, Alice Braga and Lizzy Caplan. "Crossing Over" was financed and will be distributed by the Weinstein Company in 2008. Kramer incorporated the storyline from his 1995 short film, also titled "Crossing Over," into his new feature. The subject matter holds a lot of meaning to Kramer since he is a naturalized American citizen. He received his citizenship in 2000.