Wayne and Shuster were a Canadian comedy duo formed by Johnny Wayne and Frank Shuster which was active professionally from the early 1940s until the late 1980s.

Wayne (born Louis Weingarten, May 28, 1918 – July 18, 1990) and Shuster (September 5, 1916 – January 13, 2002) were well known in Canada, and were two of Ed Sullivan's recurring guests.